Reduced Susceptibility of DNA Methyltransferase 1 Hypomorphic (Dnmt1(N/+)) Mice to Hepatic Steatosis upon Feeding Liquid Alcohol Diet

BACKGROUND: Methylation at C-5 (5-mdC) of CpG base pairs, the most abundant epigenetic modification of DNA, is catalyzed by 3 essential DNA methyltransferases (Dnmt1, Dnmt3a and Dnmt3b). Aberrations in DNA methylation and Dnmts are linked to different diseases including cancer. However, their role i...

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Detalles Bibliográficos
Autores principales: Kutay, Huban, Klepper, Corie, Wang, Bo, Hsu, Shu-hao, Datta, Jharna, Yu, Lianbo, Zhang, Xiaoli, Majumder, Sarmila, Motiwala, Tasneem, Khan, Nuzhat, Belury, Martha, McClain, Craig, Jacob, Samson, Ghoshal, Kalpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414497/
https://www.ncbi.nlm.nih.gov/pubmed/22905112
http://dx.doi.org/10.1371/journal.pone.0041949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414497/
https://www.ncbi.nlm.nih.gov/pubmed/22905112
http://dx.doi.org/10.1371/journal.pone.0041949

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