Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region

EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD) pathway. Here, we investigate the role of EDEM1 in the processing of tyrosinase, a tumour antigen overexpressed in...

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Detalles Bibliográficos
Autores principales: Marin, Marioara B., Ghenea, Simona, Spiridon, Laurentiu N., Chiritoiu, Gabriela N., Petrescu, Andrei-Jose, Petrescu, Stefana-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414498/
https://www.ncbi.nlm.nih.gov/pubmed/22905195
http://dx.doi.org/10.1371/journal.pone.0042998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414498/
https://www.ncbi.nlm.nih.gov/pubmed/22905195
http://dx.doi.org/10.1371/journal.pone.0042998

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