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Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region
EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD) pathway. Here, we investigate the role of EDEM1 in the processing of tyrosinase, a tumour antigen overexpressed in...
Autores principales: | Marin, Marioara B., Ghenea, Simona, Spiridon, Laurentiu N., Chiritoiu, Gabriela N., Petrescu, Andrei-Jose, Petrescu, Stefana-Maria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414498/ https://www.ncbi.nlm.nih.gov/pubmed/22905195 http://dx.doi.org/10.1371/journal.pone.0042998 |
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