Crystal structures of the Jak2 pseudokinase domain and the pathogenic mutant V617F

The protein tyrosine kinase Jak2 mediates signaling through numerous cytokine receptors. Jak2 possesses a pseudokinase domain (JH2) and a tyrosine kinase domain (JH1). Through unknown mechanisms, JH2 regulates the catalytic activity of JH1, and hyperactivating mutations in the JH2 region of human Ja...

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Detalles Bibliográficos
Autores principales: Bandaranayake, Rajintha M., Ungureanu, Daniela, Shan, Yibing, Shaw, David E., Silvennoinen, Olli, Hubbard, Stevan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414675/
https://www.ncbi.nlm.nih.gov/pubmed/22820988
http://dx.doi.org/10.1038/nsmb.2348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414675/
https://www.ncbi.nlm.nih.gov/pubmed/22820988
http://dx.doi.org/10.1038/nsmb.2348

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