5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription

While the roles of 5-methyl-cytosine and 5-hydroxymethyl-cytosine in epigenetic regulation of gene expression are well-established, the functional effects of 5-formyl-cytosine and 5-carboxyl-cytosine in the genome on transcription are not clear. Here we report the first systematic study of the effec...

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Autores principales: Kellinger, Matthew W., Song, Chun-Xiao, Chong, Jenny, Lu, Xing-Yu, He, Chuan, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414690/
https://www.ncbi.nlm.nih.gov/pubmed/22820989
http://dx.doi.org/10.1038/nsmb.2346
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author Kellinger, Matthew W.
Song, Chun-Xiao
Chong, Jenny
Lu, Xing-Yu
He, Chuan
Wang, Dong
author_facet Kellinger, Matthew W.
Song, Chun-Xiao
Chong, Jenny
Lu, Xing-Yu
He, Chuan
Wang, Dong
author_sort Kellinger, Matthew W.
collection PubMed
description While the roles of 5-methyl-cytosine and 5-hydroxymethyl-cytosine in epigenetic regulation of gene expression are well-established, the functional effects of 5-formyl-cytosine and 5-carboxyl-cytosine in the genome on transcription are not clear. Here we report the first systematic study of the effects of five different forms of cytosine in DNA on mammalian and yeast RNA polymerase II transcription, providing new insights into potential functional interplay between cytosine methylation status and transcription.
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spelling pubmed-34146902013-02-01 5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription Kellinger, Matthew W. Song, Chun-Xiao Chong, Jenny Lu, Xing-Yu He, Chuan Wang, Dong Nat Struct Mol Biol Article While the roles of 5-methyl-cytosine and 5-hydroxymethyl-cytosine in epigenetic regulation of gene expression are well-established, the functional effects of 5-formyl-cytosine and 5-carboxyl-cytosine in the genome on transcription are not clear. Here we report the first systematic study of the effects of five different forms of cytosine in DNA on mammalian and yeast RNA polymerase II transcription, providing new insights into potential functional interplay between cytosine methylation status and transcription. 2012-07-22 2012-08 /pmc/articles/PMC3414690/ /pubmed/22820989 http://dx.doi.org/10.1038/nsmb.2346 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kellinger, Matthew W.
Song, Chun-Xiao
Chong, Jenny
Lu, Xing-Yu
He, Chuan
Wang, Dong
5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription
title 5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription
title_full 5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription
title_fullStr 5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription
title_full_unstemmed 5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription
title_short 5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription
title_sort 5-formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of rna polymerase ii transcription
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414690/
https://www.ncbi.nlm.nih.gov/pubmed/22820989
http://dx.doi.org/10.1038/nsmb.2346
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