The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions

The phosphoinositide 3-kinase (PI3K) pathway is a central signal transduction axis controlling normal B cell homeostasis and activation in humoral immunity. The p110δ PI3K catalytic subunit has emerged as a critical mediator of multiple B cell functions. The activity of this pathway is regulated at...

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Detalles Bibliográficos
Autores principales: Pauls, Samantha D., Lafarge, Sandrine T., Landego, Ivan, Zhang, Tingting, Marshall, Aaron J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414724/
https://www.ncbi.nlm.nih.gov/pubmed/22908014
http://dx.doi.org/10.3389/fimmu.2012.00224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414724/
https://www.ncbi.nlm.nih.gov/pubmed/22908014
http://dx.doi.org/10.3389/fimmu.2012.00224

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