Heptameric Targeting Ligands against EGFR and HER2 with High Stability and Avidity

Multivalency of targeting ligands provides significantly increased binding strength towards their molecular targets. Here, we report the development of a novel heptameric targeting system, with general applications, constructed by fusing a target-binding domain with the heptamerization domain of the...

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Detalles Bibliográficos
Autores principales: Kim, Dongwook, Yan, Yitang, Valencia, C. Alexander, Liu, Rihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415411/
https://www.ncbi.nlm.nih.gov/pubmed/22912791
http://dx.doi.org/10.1371/journal.pone.0043077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415411/
https://www.ncbi.nlm.nih.gov/pubmed/22912791
http://dx.doi.org/10.1371/journal.pone.0043077

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