Cargando…
Heptameric Targeting Ligands against EGFR and HER2 with High Stability and Avidity
Multivalency of targeting ligands provides significantly increased binding strength towards their molecular targets. Here, we report the development of a novel heptameric targeting system, with general applications, constructed by fusing a target-binding domain with the heptamerization domain of the...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415411/ https://www.ncbi.nlm.nih.gov/pubmed/22912791 http://dx.doi.org/10.1371/journal.pone.0043077 |