Rescuing Alu: Recovery of New Inserts Shows LINE-1 Preserves Alu Activity through A-Tail Expansion

Alu elements are trans-mobilized by the autonomous non-LTR retroelement, LINE-1 (L1). Alu-induced insertion mutagenesis contributes to about 0.1% human genetic disease and is responsible for the majority of the documented instances of human retroelement insertion-induced disease. Here we introduce a...

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Detalles Bibliográficos
Autores principales: Wagstaff, Bradley J., Hedges, Dale J., Derbes, Rebecca S., Campos Sanchez, Rebeca, Chiaromonte, Francesca, Makova, Kateryna D., Roy-Engel, Astrid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415434/
https://www.ncbi.nlm.nih.gov/pubmed/22912586
http://dx.doi.org/10.1371/journal.pgen.1002842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415434/
https://www.ncbi.nlm.nih.gov/pubmed/22912586
http://dx.doi.org/10.1371/journal.pgen.1002842

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