Cargando…

The gut microbiota regulates bone mass in mice

The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ-free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventiona...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sjögren, Klara, Engdahl, Cecilia, Henning, Petra, Lerner, Ulf H, Tremaroli, Valentina, Lagerquist, Marie K, Bäckhed, Fredrik, Ohlsson, Claes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415623/ https://www.ncbi.nlm.nih.gov/pubmed/22407806 http://dx.doi.org/10.1002/jbmr.1588

Ejemplares similares

Assessing the Human Gut Microbiota in Metabolic Diseases
por: Karlsson, Fredrik, et al.
Publicado: (2013)

Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone mass
por: Lawenius, Lina, et al.
Publicado: (2023)

Acute fat loss does not affect bone mass
por: Lagerquist, Marie K., et al.
Publicado: (2021)

Immunoglobulin G complexes without sialic acids enhance osteoclastogenesis but do not affect arthritis‐mediated bone loss
por: Sehic, Edina, et al.
Publicado: (2020)

Periarticular Bone Loss in Antigen-Induced Arthritis
por: Engdahl, Cecilia, et al.
Publicado: (2013)

Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice
por: Ohlsson, Claes, et al.
Publicado: (2018)

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
por: Caesar, Robert, et al.
Publicado: (2015)

Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated Mice
por: Windahl, Sara H., et al.
Publicado: (2011)

SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice
por: Börjesson, Anna E., et al.
Publicado: (2016)

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice
por: Horkeby, Karin, et al.
Publicado: (2022)

Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health
por: Olsson, Lisa M, et al.
Publicado: (2020)

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2
por: Windahl, Sara H, et al.
Publicado: (2013)

Probiotics Protect Mice from Ovariectomy-Induced Cortical Bone Loss
por: Ohlsson, Claes, et al.
Publicado: (2014)

Host–microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice
por: Molinaro, Antonio, et al.
Publicado: (2017)

Gut microbial characteristics in poor appetite and undernutrition: a cohort of older adults and microbiota transfer in germ‐free mice
por: Fluitman, Kristina S., et al.
Publicado: (2022)

Symptomatic atherosclerosis is associated with an altered gut metagenome
por: Karlsson, Fredrik H., et al.
Publicado: (2012)

Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice
por: Funck-Brentano, Thomas, et al.
Publicado: (2018)

Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1(*/* )mice with collagen-induced chronic arthritis
por: Jochems, Caroline, et al.
Publicado: (2010)

SUN-744 Phosphorylation Site S122 in Estrogen Receptor α Has a Tissue-Dependent Role in Female Mice
por: Gustafsson, Karin L, et al.
Publicado: (2020)

Clinically relevant doses of vitamin A decrease cortical bone mass in mice
por: Lionikaite, Vikte, et al.
Publicado: (2018)

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
por: Tremaroli, Valentina, et al.
Publicado: (2015)

Effects of a Vegetarian Diet on Cardiometabolic Risk Factors, Gut Microbiota, and Plasma Metabolome in Subjects With Ischemic Heart Disease: A Randomized, Crossover Study
por: Djekic, Demir, et al.
Publicado: (2020)

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88
por: Larsson, Erik, et al.
Publicado: (2011)

The gut microbiota is a major regulator of androgen metabolism in intestinal contents
por: Colldén, Hannah, et al.
Publicado: (2019)

Osteomicrobiology: A New Cross-Disciplinary Research Field
por: Ohlsson, Claes, et al.
Publicado: (2017)

Membrane estrogen receptor α signaling modulates the sensitivity to estradiol treatment in a dose- and tissue- dependent manner
por: Jiang, Yiwen, et al.
Publicado: (2023)

Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass
por: Arora, Tulika, et al.
Publicado: (2017)

Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss
por: Lawenius, Lina, et al.
Publicado: (2020)

ERα Signaling in a Subset of CXCL12‐Abundant Reticular Cells Regulates Trabecular Bone in Mice
por: Scheffler, Julia M, et al.
Publicado: (2022)

Bone-Derived IGF-I Regulates Radial Bone Growth in Adult Male Mice
por: Svensson, Johan, et al.
Publicado: (2023)

A tissue-specific role of membrane-initiated ERα signaling for the effects of SERMs
por: Gustafsson, Karin L, et al.
Publicado: (2022)

Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other
por: Nilsson, Karin H., et al.
Publicado: (2022)

Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans
por: Movérare-Skrtic, Sofia, et al.
Publicado: (2019)

Effects of the selective GPER1 agonist G1 on bone growth
por: Iravani, Maryam, et al.
Publicado: (2019)

A probiotic mix partially protects against castration-induced bone loss in male mice
por: Lawenius, Lina, et al.
Publicado: (2022)

Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe(−/−) Mice
por: Lindskog Jonsson, Annika, et al.
Publicado: (2018)

Site-specific programming of the host epithelial transcriptome by the gut microbiota
por: Sommer, Felix, et al.
Publicado: (2015)

A COX‐2 Inhibitor Does Not Interfere With the Bone‐Protective Effects of Loading in Male Mice With Arthritis
por: Desai, Suchita, et al.
Publicado: (2023)

Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular Bone
por: Lagerquist, Marie K., et al.
Publicado: (2022)

The Gut Microbiota Modulates Glycaemic Control and Serum Metabolite Profiles in Non-Obese Diabetic Mice
por: Greiner, Thomas U., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ij88f9m0chlut47jfgbnqlggg2