Molecular dynamics simulations of Ago silencing complexes reveal a large repertoire of admissible ‘seed-less’ targets

To better understand the recognition mechanism of RISC and the repertoire of guide-target interactions we introduced G:U wobbles and mismatches at various positions of the microRNA (miRNA) ‘seed’ region and performed all-atom molecular dynamics simulations of the resulting Ago-miRNA:mRNA ternary com...

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Detalles Bibliográficos
Autores principales: Xia, Zhen, Clark, Peter, Huynh, Tien, Loher, Phillipe, Zhao, Yue, Chen, Huang-Wen, Rigoutsos, Isidore, Zhou, Ruhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415692/
https://www.ncbi.nlm.nih.gov/pubmed/22888400
http://dx.doi.org/10.1038/srep00569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415692/
https://www.ncbi.nlm.nih.gov/pubmed/22888400
http://dx.doi.org/10.1038/srep00569

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