An acidic oligopeptide displayed on AAV2 improves axial muscle tropism after systemic delivery

BACKGROUND: The appropriate tropism of adeno-associated virus (AAV) vectors that are systemically injected is crucial for successful gene therapy when local injection is not practical. Acidic oligopeptides have been shown to enhance drug delivery to bones. METHODS: In this study six-L aspartic acids...

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Detalles Bibliográficos
Autores principales: Lee, Ni-Chung, Falk, Darin J, Byrne, Barry J, Conlon, Thomas J, Clement, Nathalie, Porvasnik, Stacy, Jorgensen, Marda L, Potter, Mark, Erger, Kirsten E, Watson, Rachael, Ghivizzani, Steven C, Chiu, Hung-Chuan, Chien, Yin-Hsiu, Hwu, Wuh-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416570/
https://www.ncbi.nlm.nih.gov/pubmed/22709483
http://dx.doi.org/10.1186/1479-0556-10-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416570/
https://www.ncbi.nlm.nih.gov/pubmed/22709483
http://dx.doi.org/10.1186/1479-0556-10-3

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