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MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status

BACKGROUND: MicroRNA have a central role in normal haematopoiesis and are deregulated in acute myeloid leukaemia (AML). The purpose of the study was to investigate by qRT-PCR the expression of miRNAs involved in myeloid differentiation (miR-424, miR-155, miR-223, miR-17-5p) in 48 patients with cytog...

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Detalles Bibliográficos
Autores principales: Faraoni, Isabella, Laterza, Serena, Ardiri, Davide, Ciardi, Claudia, Fazi, Francesco, Lo-Coco, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416574/
https://www.ncbi.nlm.nih.gov/pubmed/22681934
http://dx.doi.org/10.1186/1756-8722-5-26