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Ectopic ERK expression induces phenotypic conversion of C10 cells and alters DNA methyltransferase expression

BACKGROUND: Many lung carcinogens activate mitogen activated protein kinase (MAPK) pathways and DNA methyltransferases (DNMTs) are under investigation as therapeutic targets for lung cancer. Our goal is to determine whether C10 type II alveolar epithelial cells are a sensitive model to investigate E...

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Detalles Bibliográficos
Autores principales: Sontag, Ryan L, Weber, Thomas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416577/
https://www.ncbi.nlm.nih.gov/pubmed/22559742
http://dx.doi.org/10.1186/1756-0500-5-217