Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan

Mitochondrial dysfunction has been a hallmark of cancer. However, whether it plays a causive role awaits to be elucidated. Here, using an animal model derived from inactivation of SUV3, a mitochondrial helicase, we demonstrated that mSuv3+/− mice harbored increased mtDNA mutations and decreased mtDN...

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Detalles Bibliográficos
Autores principales: Chen, Phang-Lang, Chen, Chi-Fen, Chen, Yumay, Guo, Xuning Emily, Huang, Chun-Kai, Shew, Jin-Yuh, Reddick, Robert L., Wallace, Douglas C., Lee, Wen-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416964/
https://www.ncbi.nlm.nih.gov/pubmed/22562243
http://dx.doi.org/10.1038/onc.2012.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416964/
https://www.ncbi.nlm.nih.gov/pubmed/22562243
http://dx.doi.org/10.1038/onc.2012.120

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