Cargando…

Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan

Mitochondrial dysfunction has been a hallmark of cancer. However, whether it plays a causive role awaits to be elucidated. Here, using an animal model derived from inactivation of SUV3, a mitochondrial helicase, we demonstrated that mSuv3+/− mice harbored increased mtDNA mutations and decreased mtDN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Phang-Lang, Chen, Chi-Fen, Chen, Yumay, Guo, Xuning Emily, Huang, Chun-Kai, Shew, Jin-Yuh, Reddick, Robert L., Wallace, Douglas C., Lee, Wen-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416964/ https://www.ncbi.nlm.nih.gov/pubmed/22562243 http://dx.doi.org/10.1038/onc.2012.120

Ejemplares similares

SUV3 Helicase and Mitochondrial Homeostasis
por: Chen, Phang-Lang
Publicado: (2023)

Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability
por: Chen, Yumay, et al.
Publicado: (2011)

Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice
por: Nojima, Aika, et al.
Publicado: (2013)

BRCA1 the Versatile Defender: Molecular to Environmental Perspectives
por: Zhong, Amy X., et al.
Publicado: (2023)

Increased Nek1 expression in Renal Cell Carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment
por: Chen, Yumay, et al.
Publicado: (2014)

Social stress shortens lifespan in mice
por: Razzoli, Maria, et al.
Publicado: (2018)

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
por: Sedic, Maja, et al.
Publicado: (2015)

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae
por: Sunshine, Anna B., et al.
Publicado: (2016)

Haploinsufficiency of syncoilin leads to hypertrophic cardiomyopathy
por: Fan, Liang-Liang, et al.
Publicado: (2022)

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
por: Ghosh, Shrestha, et al.
Publicado: (2018)

Fine Particulate Matter Leads to Unfolded Protein Response and Shortened Lifespan by Inducing Oxidative Stress in C. elegans
por: Zhao, Yunli, et al.
Publicado: (2019)

Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila
por: Kohyama-Koganeya, Ayako, et al.
Publicado: (2017)

High temperatures during microsporogenesis fatally shorten pollen lifespan
por: Iovane, Maurizio, et al.
Publicado: (2021)

Social isolation shortens lifespan through oxidative stress in ants
por: Koto, Akiko, et al.
Publicado: (2023)

Is it safe to drive SUVs?
Publicado: (1998)

Heterozygous Mutation of Opa1 in Drosophila Shortens Lifespan Mediated through Increased Reactive Oxygen Species Production
por: Tang, Sha, et al.
Publicado: (2009)

Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice
por: Pathak, Shilpa, et al.
Publicado: (2020)

The fine line between lifespan extension and shortening in response to caloric restriction
por: Szafranski, Kirk, et al.
Publicado: (2014)

Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model
por: Staber, Janice M., et al.
Publicado: (2016)

DOES THE ENERGETIC COST OF STRESS ACCELERATE BIOLOGICAL AGING AND SHORTEN LIFESPAN?
por: Picard, Martin
Publicado: (2022)

A paradox promoted by microglia cannibalism shortens the lifespan of developmental microglia
por: Gordon, Hannah, et al.
Publicado: (2023)

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model
por: Liu, Baohua, et al.
Publicado: (2013)

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy
por: Kovačević, Jovana, et al.
Publicado: (2018)

Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization Failure
por: Chen, Haixia, et al.
Publicado: (2022)

Ammonium Is Toxic for Aging Yeast Cells, Inducing Death and Shortening of the Chronological Lifespan
por: Santos, Júlia, et al.
Publicado: (2012)

Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan
por: Bernhardt, Dominik, et al.
Publicado: (2015)

Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila
por: Nash, Trevor R., et al.
Publicado: (2019)

INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis
por: Lee, Shin-Ai, et al.
Publicado: (2017)

How does genome instability affect lifespan?
por: Kobayashi, Takehiko
Publicado: (2011)

Myc-Dependent Genome Instability and Lifespan in Drosophila
por: Greer, Christina, et al.
Publicado: (2013)

A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
por: Tan, Shawn Lu Wen, et al.
Publicado: (2017)

MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity
por: Chen, Ya-qin, et al.
Publicado: (2017)

High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction
por: Choi, Shin Sik
Publicado: (2011)

An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan
por: Twumasi-Boateng, Kwame, et al.
Publicado: (2012)

Shortened Lifespan and Other Age-Related Defects in Bang Sensitive Mutants of Drosophila melanogaster
por: Reynolds, Elaine R.
Publicado: (2018)

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans
por: Liu, Yasmine J., et al.
Publicado: (2022)

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential
por: Madgwick, Suzanne, et al.
Publicado: (2022)

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
por: Delaney, Joe R., et al.
Publicado: (2020)

Is SUV Corrected for Lean Body Mass Superior to SUV of Body Weight in (68)Ga-PSMA PET/CT?
por: Aksu, Ayşegül, et al.
Publicado: (2021)

SUV(fdg): A standard-uptake-value (SUV) body habitus normalizer specific to fluorodeoxyglucose (FDG) in humans
por: Beattie, Bradley J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9eruusn73rkflotc03qvgthier