Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic

To evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiv...

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Autores principales: Chang, Hye-Sook, Endoh, Daiji, Ishida, Yushi, Takahashi, Hiroyuki, Ozawa, Shuji, Hayashi, Masanobu, Yabuki, Akira, Yamato, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417205/
https://www.ncbi.nlm.nih.gov/pubmed/22919357
http://dx.doi.org/10.1100/2012/846750
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author Chang, Hye-Sook
Endoh, Daiji
Ishida, Yushi
Takahashi, Hiroyuki
Ozawa, Shuji
Hayashi, Masanobu
Yabuki, Akira
Yamato, Osamu
author_facet Chang, Hye-Sook
Endoh, Daiji
Ishida, Yushi
Takahashi, Hiroyuki
Ozawa, Shuji
Hayashi, Masanobu
Yabuki, Akira
Yamato, Osamu
author_sort Chang, Hye-Sook
collection PubMed
description To evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiving 10 Gy of X-ray irradiation. Cell damage caused by the irradiation was quantified as comet tail moment, which represents the degree of DNA damage. X-ray-induced DNA damage was significantly decreased in both H4IIE and L5178Y cells by micromolar concentrations of NPTS and 2PTS compared with the control without the compounds. The protective effect was more potent with 2PTS than NPTS. Onions and garlic have antiradiation potential.
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spelling pubmed-34172052012-08-23 Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic Chang, Hye-Sook Endoh, Daiji Ishida, Yushi Takahashi, Hiroyuki Ozawa, Shuji Hayashi, Masanobu Yabuki, Akira Yamato, Osamu ScientificWorldJournal Research Article To evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiving 10 Gy of X-ray irradiation. Cell damage caused by the irradiation was quantified as comet tail moment, which represents the degree of DNA damage. X-ray-induced DNA damage was significantly decreased in both H4IIE and L5178Y cells by micromolar concentrations of NPTS and 2PTS compared with the control without the compounds. The protective effect was more potent with 2PTS than NPTS. Onions and garlic have antiradiation potential. The Scientific World Journal 2012-07-31 /pmc/articles/PMC3417205/ /pubmed/22919357 http://dx.doi.org/10.1100/2012/846750 Text en Copyright © 2012 Hye-Sook Chang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chang, Hye-Sook
Endoh, Daiji
Ishida, Yushi
Takahashi, Hiroyuki
Ozawa, Shuji
Hayashi, Masanobu
Yabuki, Akira
Yamato, Osamu
Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic
title Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic
title_full Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic
title_fullStr Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic
title_full_unstemmed Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic
title_short Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic
title_sort radioprotective effect of alk(en)yl thiosulfates derived from allium vegetables against dna damage caused by x-ray irradiation in cultured cells: antiradiation potential of onions and garlic
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417205/
https://www.ncbi.nlm.nih.gov/pubmed/22919357
http://dx.doi.org/10.1100/2012/846750
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