Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3

BACKGROUND AND PURPOSE: The chemokine receptor CXCR3 directs migration of T-cells in response to the ligands CXCL9/Mig, CXCL10/IP-10 and CXCL11/I-TAC. Both ligands and receptors are implicated in the pathogenesis of inflammatory disorders, including atherosclerosis and rheumatoid arthritis. Here, we...

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Detalles Bibliográficos
Autores principales: Nedjai, Belinda, Li, Hubert, Stroke, Ilana L, Wise, Emma L, Webb, Maria L, Merritt, J Robert, Henderson, Ian, Klon, Anthony E, Cole, Andrew G, Horuk, Richard, Vaidehi, Nagarajan, Pease, James E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Research Papers with Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417418/
https://www.ncbi.nlm.nih.gov/pubmed/21895630
http://dx.doi.org/10.1111/j.1476-5381.2011.01660.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417418/
https://www.ncbi.nlm.nih.gov/pubmed/21895630
http://dx.doi.org/10.1111/j.1476-5381.2011.01660.x

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