Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine

OBJECTIVE: Brucine was encapsulated into stealth liposomes using the ammonium sulfate gradient method to improve therapeutic index. MATERIALS AND METHODS: Four brucine stealth liposomal formulations were prepared, which were made from different phosphatidylcholines (PCs) with different phase transit...

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Detalles Bibliográficos
Autores principales: Chen, Jun, Yan, Guo-jun, Hu, Rong-rong, Gu, Qian-wen, Chen, Ming-lei, Gu, Wei, Chen, Zhi-peng, Cai, Bao-chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418081/
https://www.ncbi.nlm.nih.gov/pubmed/22904620
http://dx.doi.org/10.2147/IJN.S32860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418081/
https://www.ncbi.nlm.nih.gov/pubmed/22904620
http://dx.doi.org/10.2147/IJN.S32860

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