The Adaptor Protein SAP Directly Associates with CD3ζ Chain and Regulates T Cell Receptor Signaling

Mutations altering the gene encoding the SLAM associated protein (SAP) are responsible for the X-linked lymphoproliferative disease or XLP1. Its absence is correlated with a defective NKT cells development, a decrease in B cell functions and a reduced T cells and NK cells cytotoxic activities, thus...

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Detalles Bibliográficos
Autores principales: Proust, Richard, Bertoglio, Jacques, Gesbert, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418226/
https://www.ncbi.nlm.nih.gov/pubmed/22912825
http://dx.doi.org/10.1371/journal.pone.0043200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418226/
https://www.ncbi.nlm.nih.gov/pubmed/22912825
http://dx.doi.org/10.1371/journal.pone.0043200

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