Early Sorafenib-Induced Toxicity Is Associated with Drug Exposure and UGTIA9 Genetic Polymorphism in Patients with Solid Tumors: A Preliminary Study

BACKGROUND: Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharma...

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Detalles Bibliográficos
Autores principales: Boudou-Rouquette, Pascaline, Narjoz, Céline, Golmard, Jean Louis, Thomas-Schoemann, Audrey, Mir, Olivier, Taieb, Fabrice, Durand, Jean-Philippe, Coriat, Romain, Dauphin, Alain, Vidal, Michel, Tod, Michel, Loriot, Marie-Anne, Goldwasser, François, Blanchet, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418266/
https://www.ncbi.nlm.nih.gov/pubmed/22912756
http://dx.doi.org/10.1371/journal.pone.0042875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418266/
https://www.ncbi.nlm.nih.gov/pubmed/22912756
http://dx.doi.org/10.1371/journal.pone.0042875

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