Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In Vivo

Aciculatin, a natural compound extracted from the medicinal herb Chrysopogon aciculatus, shows potent anti-cancer potency. This study is the first to prove that aciculatin induces cell death in human cancer cells and HCT116 mouse xenografts due to G1 arrest and subsequent apoptosis. The primary reas...

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Detalles Bibliográficos
Autores principales: Lai, Chin-Yu, Tsai, An-Chi, Chen, Mei-Chuan, Chang, Li-Hsun, Sun, Hui-Lung, Chang, Ya-Ling, Chen, Chien-Chih, Teng, Che-Ming, Pan, Shiow-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418269/
https://www.ncbi.nlm.nih.gov/pubmed/22912688
http://dx.doi.org/10.1371/journal.pone.0042192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418269/
https://www.ncbi.nlm.nih.gov/pubmed/22912688
http://dx.doi.org/10.1371/journal.pone.0042192

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