Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks

The Arp2/3-activator Wiskott–Aldrich syndrome protein and Scar homologue (WASH) is suggested to regulate actin-dependent membrane scission during endosomal sorting, but its cellular roles have not been fully elucidated. To investigate WASH function, we generated tamoxifen-inducible WASH-knockout mou...

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Detalles Bibliográficos
Autores principales: Gomez, Timothy S., Gorman, Jacquelyn A., Artal-Martinez de Narvajas, Amaia, Koenig, Alexander O., Billadeau, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418315/
https://www.ncbi.nlm.nih.gov/pubmed/22718907
http://dx.doi.org/10.1091/mbc.E12-02-0101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418315/
https://www.ncbi.nlm.nih.gov/pubmed/22718907
http://dx.doi.org/10.1091/mbc.E12-02-0101

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