Hippocampal CA1 Pyramidal Neurons of Mecp2 Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage

Alterations in dendritic spines have been documented in numerous neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, an X chromosome-linked disorder associated with mutations in MECP2, is the leading cause of intellectual disabilities in women. Neurons in Mecp2-deficient mice show lowe...

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Detalles Bibliográficos
Autores principales: Chapleau, Christopher A., Boggio, Elena Maria, Calfa, Gaston, Percy, Alan K., Giustetto, Maurizio, Pozzo-Miller, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418521/
https://www.ncbi.nlm.nih.gov/pubmed/22919518
http://dx.doi.org/10.1155/2012/976164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418521/
https://www.ncbi.nlm.nih.gov/pubmed/22919518
http://dx.doi.org/10.1155/2012/976164

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