Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential

Protein kinase C isoform θ (PKCθ) is a key modulator of TCR signaling and mediates activation of NF-κB, NF-AT, and AP-1 transcription factors. Although in vitro studies of PKCθ(-/-) T cells have shown impaired activation responses, in vivo studies indicate that PKCθ requirement is not universal. Whi...

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Detalles Bibliográficos
Autores principales: Bronk, Crystina C., Yu, Xue-Zhong, Beg, Amer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418525/
https://www.ncbi.nlm.nih.gov/pubmed/22912640
http://dx.doi.org/10.3389/fimmu.2012.00259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418525/
https://www.ncbi.nlm.nih.gov/pubmed/22912640
http://dx.doi.org/10.3389/fimmu.2012.00259

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