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Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential
Protein kinase C isoform θ (PKCθ) is a key modulator of TCR signaling and mediates activation of NF-κB, NF-AT, and AP-1 transcription factors. Although in vitro studies of PKCθ(-/-) T cells have shown impaired activation responses, in vivo studies indicate that PKCθ requirement is not universal. Whi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Research Foundation
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418525/ https://www.ncbi.nlm.nih.gov/pubmed/22912640 http://dx.doi.org/10.3389/fimmu.2012.00259 |