Does a loss of TDP-43 function cause neurodegeneration?

In 2006, TAR-DNA binding protein 43 kDa (TDP-43) was discovered to be in the intracellular aggregates in the degenerating cells in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two fatal neurodegenerative diseases [1,2]. ALS causes motor neuron degeneration leadin...

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Detalles Bibliográficos
Autor principal: Xu, Zuo-Shang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419078/
https://www.ncbi.nlm.nih.gov/pubmed/22697423
http://dx.doi.org/10.1186/1750-1326-7-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419078/
https://www.ncbi.nlm.nih.gov/pubmed/22697423
http://dx.doi.org/10.1186/1750-1326-7-27

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