Cargando…

Does a loss of TDP-43 function cause neurodegeneration?

In 2006, TAR-DNA binding protein 43 kDa (TDP-43) was discovered to be in the intracellular aggregates in the degenerating cells in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two fatal neurodegenerative diseases [1,2]. ALS causes motor neuron degeneration leadin...

Descripción completa

Detalles Bibliográficos
Autor principal:	Xu, Zuo-Shang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419078/ https://www.ncbi.nlm.nih.gov/pubmed/22697423 http://dx.doi.org/10.1186/1750-1326-7-27

Ejemplares similares

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions
por: Ling, Shuo-Chien
Publicado: (2018)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
por: Xie, Manling, et al.
Publicado: (2021)

TDP-43 and ER Stress in Neurodegeneration: Friends or Foes?
por: de Mena, Lorena, et al.
Publicado: (2021)

An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration
por: Flores, Brittany N., et al.
Publicado: (2019)

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
por: Melamed, Ze’ev, et al.
Publicado: (2019)

Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans
por: Vaccaro, Alexandra, et al.
Publicado: (2012)

The Role of TDP-43 in Military-Relevant TBI and Chronic Neurodegeneration
por: Heyburn, Lanier, et al.
Publicado: (2019)

Aggregation of TDP-43 fragments triggers cellular aberrant function: implication in neurodegeneration
por: Che, Meixia, et al.
Publicado: (2012)

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD–ALS spectrum disorders
por: Janssens, Jonathan, et al.
Publicado: (2013)

TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander
por: Banks, Gareth T., et al.
Publicado: (2008)

To Be or Not To Be…Toxic—Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration?
por: Loganathan, Suvithanandhini, et al.
Publicado: (2020)

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
por: Kasu, Yasar Arfat T., et al.
Publicado: (2022)

RNA targets of TDP-43: Which one is more important in neurodegeneration?
por: Halim, Dilara, et al.
Publicado: (2022)

Mechanisms underlying TDP-43 pathology and neurodegeneration: An updated Mini-Review
por: Nilaver, Benjamin I., et al.
Publicado: (2023)

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
por: Diaper, Danielle C., et al.
Publicado: (2013)

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
por: Krug, Lisa, et al.
Publicado: (2017)

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice
por: Yang, Chunxing, et al.
Publicado: (2022)

Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration
por: Laneve, Pietro, et al.
Publicado: (2017)

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
por: Lee, Shinrye, et al.
Publicado: (2020)

Molecular, functional, and pathological aspects of TDP-43 fragmentation
por: Chhangani, Deepak, et al.
Publicado: (2021)

Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD
por: Yusuff, Tanzeen, et al.
Publicado: (2023)

m(1)A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration
por: Sun, Yuxiang, et al.
Publicado: (2023)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
por: Tamaki, Yoshitaka, et al.
Publicado: (2022)

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration
por: Taylor, Laura M., et al.
Publicado: (2018)

TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia
por: Archbold, Hilary C., et al.
Publicado: (2018)

Molecular Neuropathology of TDP-43 Proteinopathies
por: Neumann, Manuela
Publicado: (2009)

Metals in ALS TDP-43 Pathology
por: Koski, Lassi, et al.
Publicado: (2021)

TDP-43 Pathology in Alzheimer’s Disease
por: Meneses, Axel, et al.
Publicado: (2021)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

Drosophila Answers to TDP-43 Proteinopathies
por: Romano, Maurizio, et al.
Publicado: (2012)

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
por: Herdewyn, Sarah, et al.
Publicado: (2014)

Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis
por: Fang, Minggang, et al.
Publicado: (2023)

Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice
por: Campbell, Kaitlyn M., et al.
Publicado: (2021)

TDP-43 misexpression causes defects in dendritic growth
por: Herzog, Josiah J., et al.
Publicado: (2017)

Reducing TDP-43 aggregation does not prevent its cytotoxicity
por: Liu, Rui, et al.
Publicado: (2013)

Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene
por: Zhou, Hongxia, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_4e53ab8ld8amatlc95kon4si8c