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Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation
Cell polarity is essential to the function of many cell types, such as epithelial cells and neurons. The Discs large (Dlg) scaffolding protein was identified in Drosophila as a major regulator of basolateral epithelial identity. Four Dlg orthologs (Dlg1 through 4) are found in vertebrates, and mutat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419117/ https://www.ncbi.nlm.nih.gov/pubmed/22896795 http://dx.doi.org/10.4161/cib.19792 |