FASCAPLYSIN as a Specific Inhibitor for CDK4: Insights from Molecular Modelling

Cyclin-dependent kinases (CDKs) play a key role in the cell cycle and are important anti-cancer drug targets. The natural product fascaplysin inhibits CDK4 with surprising selectivity (IC(50) = 0.4 µM) compared to the close homolog CDK2 (IC(50) = 500 µM). Free energy calculations of the positively c...

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Detalles Bibliográficos
Autores principales: Shafiq, Muhammad Imtiaz, Steinbrecher, Thomas, Schmid, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419161/
https://www.ncbi.nlm.nih.gov/pubmed/22905154
http://dx.doi.org/10.1371/journal.pone.0042612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419161/
https://www.ncbi.nlm.nih.gov/pubmed/22905154
http://dx.doi.org/10.1371/journal.pone.0042612

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