Identification of Novel Piperazinylquinoxaline Derivatives as Potent Phosphoinositide 3-Kinase (PI3K) Inhibitors

BACKGROUND: Development of small-molecule inhibitors targeting phosphoinositide 3-kinase (PI3K) has been an appealing strategy for the treatment of various types of cancers. METHODOLOGY/PRINCIPAL FINDING: Our approach was to perform structural modification and optimization based on previously identi...

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Detalles Bibliográficos
Autores principales: Wu, Peng, Su, Yi, Guan, Xianghong, Liu, Xiaowen, Zhang, Jiankang, Dong, Xiaowu, Huang, Wenhai, Hu, Yongzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419191/
https://www.ncbi.nlm.nih.gov/pubmed/22905224
http://dx.doi.org/10.1371/journal.pone.0043171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419191/
https://www.ncbi.nlm.nih.gov/pubmed/22905224
http://dx.doi.org/10.1371/journal.pone.0043171

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