Overexpression of MN1 Confers Resistance to Chemotherapy, Accelerates Leukemia Onset, and Suppresses p53 and Bim Induction

BACKGROUND: The transcriptional co-activator MN1 confers a worse prognosis for patients with acute myeloid leukemia (AML) when highly expressed; however, the mechanisms involved are unknown. We sought to model the effects of high MN1 expression in AML models to explore the underlying mechanisms. MET...

Descripción completa

Detalles Bibliográficos
Autor principal: Pardee, Timothy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419213/
https://www.ncbi.nlm.nih.gov/pubmed/22905229
http://dx.doi.org/10.1371/journal.pone.0043185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419213/
https://www.ncbi.nlm.nih.gov/pubmed/22905229
http://dx.doi.org/10.1371/journal.pone.0043185

Ejemplares similares