A Synthetic Peptide with the Putative Iron Binding Motif of Amyloid Precursor Protein (APP) Does Not Catalytically Oxidize Iron

The β-amyloid precursor protein (APP), which is a key player in Alzheimer's disease, was recently reported to possess an Fe(II) binding site within its E2 domain which exhibits ferroxidase activity [Duce et al. 2010, Cell 142: 857]. The putative ligands of this site were compared to those in th...

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Detalles Bibliográficos
Autores principales: Ebrahimi, Kourosh Honarmand, Hagedoorn, Peter-Leon, Hagen, Wilfred R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419245/
https://www.ncbi.nlm.nih.gov/pubmed/22916096
http://dx.doi.org/10.1371/journal.pone.0040287