Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland

BACKGROUND: Polymorphisms within the MTHFD1L gene were previously associated with risk of neural tube defects in Ireland. We sought to test the most significant MTHFD1L polymorphisms for an association with risk of cleft in an Irish cohort. This required the development of a new melting curve assay...

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Detalles Bibliográficos
Autores principales: Minguzzi, Stefano, Molloy, Anne M, Peadar, Kirke, Mills, James, Scott, John M, Troendle, James, Pangilinan, Faith, Brody, Lawrence, Parle-McDermott, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419639/
https://www.ncbi.nlm.nih.gov/pubmed/22520921
http://dx.doi.org/10.1186/1471-2350-13-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419639/
https://www.ncbi.nlm.nih.gov/pubmed/22520921
http://dx.doi.org/10.1186/1471-2350-13-29

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