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PCR Biases Distort Bacterial and Archaeal Community Structure in Pyrosequencing Datasets
As 16S rRNA gene targeted massively parallel sequencing has become a common tool for microbial diversity investigations, numerous advances have been made to minimize the influence of sequencing and chimeric PCR artifacts through rigorous quality control measures. However, there has been little effor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419673/ https://www.ncbi.nlm.nih.gov/pubmed/22905208 http://dx.doi.org/10.1371/journal.pone.0043093 |