Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones

P-glycoprotein, encoded by the multidrug resistance gene MDR1, is an ATP-driven drug efflux pump which is highly expressed at the blood-brain barrier of vertebrates. Drug efflux of macrocyclic lactones by P-glycoprotein is highly relevant for the therapeutic safety of macrocyclic lactones, as thereb...

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Detalles Bibliográficos
Autores principales: Geyer, Joachim, Janko, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419875/
https://www.ncbi.nlm.nih.gov/pubmed/22039792
http://dx.doi.org/10.2174/138920112800399301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419875/
https://www.ncbi.nlm.nih.gov/pubmed/22039792
http://dx.doi.org/10.2174/138920112800399301

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