Cargando…

Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies

BACKGROUND: Despite focused research in conventional therapies and considerable advances in the understanding of the molecular carcinogenesis of head and neck squamous cell carcinoma (HNSCC), the 5-year survival rate for patients with advanced disease remains ∼15–20%. The major causes of HNSCC-relat...

Descripción completa

Detalles Bibliográficos
Autores principales:	St John, M A, Wang, G, Luo, J, Dohadwala, M, Hu, D, Lin, Y, Dennis, M, Lee, J M, Elashoff, D, Lawhon, T, Zaknoen, S L, Burrows, F J, Dubinett, S M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419945/ https://www.ncbi.nlm.nih.gov/pubmed/22828609 http://dx.doi.org/10.1038/bjc.2012.203

Ejemplares similares

Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis
por: Smith, Julianne N. P., et al.
Publicado: (2020)

Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer
por: Shaw, R J, et al.
Publicado: (2009)

Upregulation of MAPK pathway is associated with survival in castrate-resistant prostate cancer
por: Mukherjee, R, et al.
Publicado: (2011)

Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy response in triple-negative breast cancer
por: Darb-Esfahani, S, et al.
Publicado: (2012)

MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma
por: Fisher, O M, et al.
Publicado: (2015)

Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
por: Zhang, Yichao, et al.
Publicado: (2021)

Upregulation of Cyclooxygenase-2/Prostaglandin E(2) (COX-2/PGE(2)) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer
por: Kochel, Tyler J., et al.
Publicado: (2016)

15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration
por: Smith, Julianne N.P., et al.
Publicado: (2021)

Expression of the proteolysis-inducing factor core peptide mRNA is upregulated in both tumour and adjacent normal tissue in gastro-oesophageal malignancy
por: Deans, D A C, et al.
Publicado: (2006)

15-PGDH regulates hematopoietic and gastrointestinal fitness during aging
por: Ho, Won Jin, et al.
Publicado: (2022)

Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients
por: Jie, H-B, et al.
Publicado: (2013)

Upregulation of cancer-associated myofibroblasts by TGF-β from scirrhous gastric carcinoma cells
por: Fuyuhiro, Y, et al.
Publicado: (2011)

Prognostic significance of CD44 variant 2 upregulation in colorectal cancer
por: Ozawa, M, et al.
Publicado: (2014)

NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression
por: McCall, P, et al.
Publicado: (2012)

Assessment of DNA methylation status in early stages of breast cancer development
por: van Hoesel, A Q, et al.
Publicado: (2013)

Upregulated ankyrin repeat-rich membrane spanning protein contributes to tumour progression in cutaneous melanoma
por: Liao, Y H, et al.
Publicado: (2011)

A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis
por: Nam, S Y, et al.
Publicado: (2011)

Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer
por: Andersen, J B, et al.
Publicado: (2006)

DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression
por: Ismail, I A, et al.
Publicado: (2014)

Identification of serum CCL15 in hepatocellular carcinoma
por: Li, Y, et al.
Publicado: (2013)

Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease
por: Helms, M W, et al.
Publicado: (2008)

Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking
por: Sugio, K, et al.
Publicado: (2006)

Polymer Microparticles Prolong Delivery of the 15-PGDH Inhibitor SW033291
por: Dogan, Alan B., et al.
Publicado: (2021)

Upregulated FGFR1 expression is associated with the transition of hormone-naive to castrate-resistant prostate cancer
por: Armstrong, K, et al.
Publicado: (2011)

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86
por: Beskow, C, et al.
Publicado: (2009)

MicroRNA-15b is induced with E2F-controlled genes in HPV-related cancer
por: Myklebust, M P, et al.
Publicado: (2011)

Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system
por: Huang, Wei, et al.
Publicado: (2023)

Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis
por: Liu, W M, et al.
Publicado: (2012)

Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma
por: Yang, H, et al.
Publicado: (2015)

Detection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT–PCR detection of cytokeratin 19 mRNA
por: Tao, L, et al.
Publicado: (2006)

Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy
por: Manton, D J, et al.
Publicado: (2006)

Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy
por: Jürgensmeier, J M, et al.
Publicado: (2013)

Inhibition of transforming growth factor-β-activated kinase-1 blocks cancer cell adhesion, invasion, and metastasis
por: Ray, D M, et al.
Publicado: (2012)

Ovarian carcinoma diagnosis: the clinical impact of 15 years of change
por: Kommoss, Stefan, et al.
Publicado: (2016)

Performance of cytology and human papillomavirus testing in relation to the menstrual cycle
por: Sherman, M E, et al.
Publicado: (2006)

Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival
por: Hanly, A M, et al.
Publicado: (2006)

RNA helicase DHX15 acts as a tumour suppressor in glioma
por: Ito, Shingo, et al.
Publicado: (2017)

Bcl-2 and β(1)-integrin predict survival in a tissue microarray of small cell lung cancer
por: Lawson, M H, et al.
Publicado: (2010)

Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes
por: Loyo, M, et al.
Publicado: (2012)

An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: a Glasgow Inflammation Outcome Study
por: Proctor, M J, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9u09u148v2qcj1lfo8astqd89r