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A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications

BACKGROUND: Pyridoxine is frequently used to treat capecitabine-induced hand–foot syndrome (HFS), although the evidence of benefit is lacking. We performed a randomised placebo-controlled trial to determine whether pyridoxine could avoid the need for capecitabine dose modifications and improve outco...

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Autores principales: Corrie, P G, Bulusu, R, Wilson, C B, Armstrong, G, Bond, S, Hardy, R, Lao-Sirieix, S, Parashar, D, Ahmad, A, Daniel, F, Hill, M, Wilson, G, Blesing, C, Moody, A M, McAdam, K, Osborne, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419962/
https://www.ncbi.nlm.nih.gov/pubmed/22814578
http://dx.doi.org/10.1038/bjc.2012.318
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author Corrie, P G
Bulusu, R
Wilson, C B
Armstrong, G
Bond, S
Hardy, R
Lao-Sirieix, S
Parashar, D
Ahmad, A
Daniel, F
Hill, M
Wilson, G
Blesing, C
Moody, A M
McAdam, K
Osborne, M
author_facet Corrie, P G
Bulusu, R
Wilson, C B
Armstrong, G
Bond, S
Hardy, R
Lao-Sirieix, S
Parashar, D
Ahmad, A
Daniel, F
Hill, M
Wilson, G
Blesing, C
Moody, A M
McAdam, K
Osborne, M
author_sort Corrie, P G
collection PubMed
description BACKGROUND: Pyridoxine is frequently used to treat capecitabine-induced hand–foot syndrome (HFS), although the evidence of benefit is lacking. We performed a randomised placebo-controlled trial to determine whether pyridoxine could avoid the need for capecitabine dose modifications and improve outcomes. METHODS: A total of 106 patients planned for palliative single-agent capecitabine (53 in each arm, 65%/ 35% colorectal/breast cancer) were randomised to receive either concomitant pyridoxine (50 mg po) or matching placebo three times daily. RESULTS: Compared with placebo, pyridoxine use was associated with an increased rate of avoiding capecitabine dose modifications (37% vs 23%, relative risk 0.59, 95% CI 0.29, 1.20, P=0.15) and fewer grade 3/4 HFS-related adverse events (9% vs 17%, odds ratio 0.51, 95% CI 0.15–1.6, P=0.26). Use of pyridoxine did not improve response rate or progression-free survival. CONCLUSION: Pyridoxine may reduce the need for capecitabine dose modifications and the incidence of severe HFS, but does not impact on antitumour effect.
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spelling pubmed-34199622013-08-07 A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications Corrie, P G Bulusu, R Wilson, C B Armstrong, G Bond, S Hardy, R Lao-Sirieix, S Parashar, D Ahmad, A Daniel, F Hill, M Wilson, G Blesing, C Moody, A M McAdam, K Osborne, M Br J Cancer Short Communication BACKGROUND: Pyridoxine is frequently used to treat capecitabine-induced hand–foot syndrome (HFS), although the evidence of benefit is lacking. We performed a randomised placebo-controlled trial to determine whether pyridoxine could avoid the need for capecitabine dose modifications and improve outcomes. METHODS: A total of 106 patients planned for palliative single-agent capecitabine (53 in each arm, 65%/ 35% colorectal/breast cancer) were randomised to receive either concomitant pyridoxine (50 mg po) or matching placebo three times daily. RESULTS: Compared with placebo, pyridoxine use was associated with an increased rate of avoiding capecitabine dose modifications (37% vs 23%, relative risk 0.59, 95% CI 0.29, 1.20, P=0.15) and fewer grade 3/4 HFS-related adverse events (9% vs 17%, odds ratio 0.51, 95% CI 0.15–1.6, P=0.26). Use of pyridoxine did not improve response rate or progression-free survival. CONCLUSION: Pyridoxine may reduce the need for capecitabine dose modifications and the incidence of severe HFS, but does not impact on antitumour effect. Nature Publishing Group 2012-08-07 2012-07-19 /pmc/articles/PMC3419962/ /pubmed/22814578 http://dx.doi.org/10.1038/bjc.2012.318 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Corrie, P G
Bulusu, R
Wilson, C B
Armstrong, G
Bond, S
Hardy, R
Lao-Sirieix, S
Parashar, D
Ahmad, A
Daniel, F
Hill, M
Wilson, G
Blesing, C
Moody, A M
McAdam, K
Osborne, M
A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
title A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
title_full A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
title_fullStr A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
title_full_unstemmed A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
title_short A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
title_sort randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419962/
https://www.ncbi.nlm.nih.gov/pubmed/22814578
http://dx.doi.org/10.1038/bjc.2012.318
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