Cargando…

Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer

BACKGROUND: MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS: We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sasahira, T, Kurihara, M, Bhawal, U K, Ueda, N, Shimomoto, T, Yamamoto, K, Kirita, T, Kuniyasu, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419968/ https://www.ncbi.nlm.nih.gov/pubmed/22836510 http://dx.doi.org/10.1038/bjc.2012.330

Ejemplares similares

Prox1 and FOXC2 Act as Regulators of Lymphangiogenesis and Angiogenesis in Oral Squamous Cell Carcinoma
por: Sasahira, Tomonori, et al.
Publicado: (2014)

Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma
por: Kurihara, M, et al.
Publicado: (2013)

LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration
por: Sasahira, Tomonori, et al.
Publicado: (2016)

Role of lymphangiogenesis in epithelial ovarian cancer
por: Sundar, S S, et al.
Publicado: (2006)

Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells
por: Hirata, H, et al.
Publicado: (2013)

Platelet releasate promotes breast cancer growth and angiogenesis via VEGF–integrin cooperative signalling
por: Jiang, Lei, et al.
Publicado: (2017)

The proline TP53 variant stimulates likely lymphangiogenesis in an orthotopic mouse model of pancreatic cancer
por: Otto, N, et al.
Publicado: (2012)

Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors
por: Xu, Y, et al.
Publicado: (2012)

Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro
por: Wu, G, et al.
Publicado: (2011)

Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer
por: Van den Eynden, G G, et al.
Publicado: (2006)

Downregulation of miR-302c and miR-520c by 1,25(OH)2D3 treatment enhances the susceptibility of tumour cells to natural killer cell-mediated cytotoxicity
por: Min, D, et al.
Publicado: (2013)

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma
por: Pritchard-Jones, R O, et al.
Publicado: (2007)

Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer
por: Kut, C, et al.
Publicado: (2007)

MicroRNA-126 inhibits invasion in bladder cancer via regulation of ADAM9
por: Jia, A Y, et al.
Publicado: (2014)

Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis
por: Mohammed, R A A, et al.
Publicado: (2007)

Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis
por: Osawa, T, et al.
Publicado: (2013)

Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients
por: Meng, Xiaodan, et al.
Publicado: (2015)

VEGF directly suppresses activation of T cells from ascites secondary to ovarian cancer via VEGF receptor type 2
por: Gavalas, N G, et al.
Publicado: (2012)

Downregulated miR-646 in clear cell renal carcinoma correlated with tumour metastasis by targeting the nin one binding protein (NOB1)
por: Li, W, et al.
Publicado: (2014)

VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo
por: Rennel, E S, et al.
Publicado: (2009)

Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer
por: Huh, J H, et al.
Publicado: (2013)

Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival
por: Ino, K, et al.
Publicado: (2006)

The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer
por: Yoshino, H, et al.
Publicado: (2011)

Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells
por: Hirata, H, et al.
Publicado: (2014)

Non-SMC Condensin I Complex Subunit H (NCAPH) Is Associated with Lymphangiogenesis and Drug Resistance in Oral Squamous Cell Carcinoma
por: Shimomura, Hiroyuki, et al.
Publicado: (2019)

miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer
por: Chiyomaru, T, et al.
Publicado: (2010)

Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
por: Wang, Min, et al.
Publicado: (2019)

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer
por: Boneberg, E-M, et al.
Publicado: (2009)

Downregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma
por: Boldrup, L, et al.
Publicado: (2015)

miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer
por: Zhang, J, et al.
Publicado: (2012)

Loss of Coxsackie and adenovirus receptor downregulates α-catenin expression
por: Stecker, K, et al.
Publicado: (2009)

Purinergic regulation of vascular endothelial growth factor signaling in angiogenesis
por: Rumjahn, S M, et al.
Publicado: (2009)

HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium
por: Kurosu, T, et al.
Publicado: (2011)

Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer
por: Kaneda, H, et al.
Publicado: (2011)

MiR-126 Modulates Angiogenesis in Breast Cancer by Targeting VEGF-A -mRNA
por: Alhasan, Layla
Publicado: (2019)

miR-21 and miR-155 are associated with mitotic activity and lesion depth of borderline melanocytic lesions
por: Grignol, V, et al.
Publicado: (2011)

Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma
por: Tanaka, T, et al.
Publicado: (2014)

Ubiquitous mitochondrial creatine kinase downregulated in oral squamous cell carcinoma
por: Onda, T, et al.
Publicado: (2006)

Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1
por: Nishioka, N, et al.
Publicado: (2011)

MicroRNA-126 and epidermal growth factor-like domain 7–an angiogenic couple of importance in metastatic colorectal cancer. Results from the Nordic ACT trial
por: Hansen, T F, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_v69km8g3bomn8q7rc8luanf1o1