A novel mechanism for ERK-dependent regulation of IL4 transcription during human Th2-cell differentiation

We demonstrate that the mitogen-activated protein kinases extracellular signal-regulated kinase (ERK)-1 and ERK-2 have a central role in mediating T-cell receptor-dependent induction of IL4 expression in human CD4(+) T cells. Significantly, this involved a novel mechanism wherein receptor cross-link...

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Detalles Bibliográficos
Autores principales: Tripathi, Parul, Sahoo, Naresh, Ullah, Ubaid, Kallionpää, Henna, Suneja, Amita, Lahesmaa, Riitta, Rao, Kanury V S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419974/
https://www.ncbi.nlm.nih.gov/pubmed/21989417
http://dx.doi.org/10.1038/icb.2011.87

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419974/
https://www.ncbi.nlm.nih.gov/pubmed/21989417
http://dx.doi.org/10.1038/icb.2011.87

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