Small-Molecule Inhibition of BRDT for Male Contraception

A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report...

Descripción completa

Detalles Bibliográficos
Autores principales: Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420011/
https://www.ncbi.nlm.nih.gov/pubmed/22901802
http://dx.doi.org/10.1016/j.cell.2012.06.045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420011/
https://www.ncbi.nlm.nih.gov/pubmed/22901802
http://dx.doi.org/10.1016/j.cell.2012.06.045

Ejemplares similares