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Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and is associated with high levels of psychological distress. We have shown that beta-adrenergic receptors (β-ARs), which are activated by stress neurotransmitters, regulate PDAC cells via cyclic AMP (cAMP)-dependent signaling in vitro, th...

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Detalles Bibliográficos
Autores principales: Al-Wadei, Hussein A. N., Al-Wadei, Mohammed H., Ullah, Mohammad F., Schuller, Hildegard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420877/
https://www.ncbi.nlm.nih.gov/pubmed/22916251
http://dx.doi.org/10.1371/journal.pone.0043376