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PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development

Vulval development in Caenorhabditis elegans serves as an excellent model to examine the crosstalk between different conserved signaling pathways that are deregulated in human cancer. The concerted action of the RAS/MAPK, NOTCH, and WNT pathways determines an invariant pattern of cell fates in three...

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Detalles Bibliográficos
Autores principales: Nakdimon, Itay, Walser, Michael, Fröhli, Erika, Hajnal, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420937/
https://www.ncbi.nlm.nih.gov/pubmed/22916028
http://dx.doi.org/10.1371/journal.pgen.1002881