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Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease

Brain connectivity studies have revealed that highly connected ‘hub’ regions are particularly vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early stage. Recently, excessive local neuronal activity has been shown to increase amyloid deposition. In this study we use a...

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Detalles Bibliográficos
Autores principales: de Haan, Willem, Mott, Katherine, van Straaten, Elisabeth C. W., Scheltens, Philip, Stam, Cornelis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420961/
https://www.ncbi.nlm.nih.gov/pubmed/22915996
http://dx.doi.org/10.1371/journal.pcbi.1002582