Cargando…

Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease

Brain connectivity studies have revealed that highly connected ‘hub’ regions are particularly vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early stage. Recently, excessive local neuronal activity has been shown to increase amyloid deposition. In this study we use a...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Haan, Willem, Mott, Katherine, van Straaten, Elisabeth C. W., Scheltens, Philip, Stam, Cornelis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420961/ https://www.ncbi.nlm.nih.gov/pubmed/22915996 http://dx.doi.org/10.1371/journal.pcbi.1002582

Ejemplares similares

Declining functional connectivity and changing hub locations in Alzheimer’s disease: an EEG study
por: Engels, Marjolein MA, et al.
Publicado: (2015)

Eyes-closed task-free electroencephalography in clinical trials for Alzheimer’s disease: an emerging method based upon brain dynamics
por: van Straaten, Elisabeth CW, et al.
Publicado: (2014)

Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease
por: de Haan, Willem, et al.
Publicado: (2017)

Slowing of Hippocampal Activity Correlates with Cognitive Decline in Early Onset Alzheimer’s Disease. An MEG Study with Virtual Electrodes
por: Engels, Marjolein M. A., et al.
Publicado: (2016)

Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
por: van Straaten, Elisabeth CW, et al.
Publicado: (2012)

A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing
por: van Nifterick, Anne M., et al.
Publicado: (2022)

Oscillatory Activity of the Hippocampus in Prodromal Alzheimer’s Disease: A Source-Space Magnetoencephalography Study
por: Luppi, Janne J., et al.
Publicado: (2022)

Magnetoencephalography for the Detection of Intervention Effects of a Specific Nutrient Combination in Patients with Mild Alzheimer’s Disease: Results from an Exploratory Double-Blind, Randomized, Controlled Study
por: van Straaten, Elisabeth C. W., et al.
Publicado: (2016)

Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory
por: de Haan, Willem, et al.
Publicado: (2009)

Single-Subject Grey Matter Graphs in Alzheimer's Disease
por: Tijms, Betty M., et al.
Publicado: (2013)

Correction: Single-Subject Grey Matter Graphs in Alzheimer's Disease
por: Tijms, Betty M., et al.
Publicado: (2013)

The Effect of Souvenaid on Functional Brain Network Organisation in Patients with Mild Alzheimer’s Disease: A Randomised Controlled Study
por: de Waal, Hanneke, et al.
Publicado: (2014)

The predictive value of normal EEGs in dementia due to Alzheimer’s disease
por: Briels, Casper T., et al.
Publicado: (2021)

Reproducibility of EEG functional connectivity in Alzheimer’s disease
por: Briels, Casper T., et al.
Publicado: (2020)

Sensitive and reproducible MEG resting-state metrics of functional connectivity in Alzheimer’s disease
por: Schoonhoven, Deborah N., et al.
Publicado: (2022)

EEG Characteristics of Dementia With Lewy Bodies, Alzheimer’s Disease and Mixed Pathology
por: van der Zande, Jessica J., et al.
Publicado: (2018)

Strong Relation Between an EEG Functional Connectivity Measure and Postmenstrual Age: A New Potential Tool for Measuring Neonatal Brain Maturation
por: van de Pol, Laura Anna, et al.
Publicado: (2018)

MEG Beamformer-Based Reconstructions of Functional Networks in Mild Cognitive Impairment
por: López, Maria E., et al.
Publicado: (2017)

A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer’s disease
por: Alexandersen, Christoffer G., et al.
Publicado: (2023)

Random forest to differentiate dementia with Lewy bodies from Alzheimer's disease
por: Dauwan, Meenakshi, et al.
Publicado: (2016)

Network-level permutation entropy of resting-state MEG recordings: A novel biomarker for early-stage Alzheimer’s disease?
por: Scheijbeler, Elliz P., et al.
Publicado: (2022)

Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials
por: Scheijbeler, Elliz P., et al.
Publicado: (2023)

Integrative EEG biomarkers predict progression to Alzheimer's disease at the MCI stage
por: Poil, Simon-Shlomo, et al.
Publicado: (2013)

Directional information flow in patients with Alzheimer's disease. A source-space resting-state MEG study
por: Engels, M.M.A., et al.
Publicado: (2017)

Mechanical vulnerability explains size-dependent mortality of reef corals
por: Madin, Joshua S, et al.
Publicado: (2014)

Cognitive Profiles and Hub Vulnerability in Parkinson's Disease
por: Lin, Sue-Jin, et al.
Publicado: (2018)

Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?
por: Nesse, Randolph M, et al.
Publicado: (2017)

Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer’s disease patients
por: van Nifterick, Anne M., et al.
Publicado: (2023)

In Vitro Enhancement of Respiratory Syncytial Virus Infection by Maternal Antibodies Does Not Explain Disease Severity in Infants
por: van Erp, Elisabeth A., et al.
Publicado: (2017)

Imaging in Alzheimer's disease
por: Scheltens, Philip
Publicado: (2009)

Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity
por: Sanz-Arigita, Ernesto J., et al.
Publicado: (2010)

Dynamic hub load predicts cognitive decline after resective neurosurgery
por: Carbo, Ellen W. S., et al.
Publicado: (2017)

Identification of the Hub Genes in Alzheimer's Disease
por: Gui, Huiwen, et al.
Publicado: (2021)

Retinal thickness correlates with parietal cortical atrophy in early-onset Alzheimer's disease and controls
por: den Haan, Jurre, et al.
Publicado: (2017)

Distance-dependent reconfiguration of hubs in Alzheimer’s disease: a cross-tissue functional network study
por: Zhang, Xingxing, et al.
Publicado: (2023)

Network Hyperexcitability in Early Alzheimer’s Disease: Is Functional Connectivity a Potential Biomarker?
por: Stam, C. J., et al.
Publicado: (2023)

The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration
por: Grill, Brock, et al.
Publicado: (2016)

Microbiota mitochondria disorders as hubs for early age-related macular degeneration
por: Fehér, János, et al.
Publicado: (2022)

EEG Alpha and Beta Band Functional Connectivity and Network Structure Mark Hub Overload in Mild Cognitive Impairment During Memory Maintenance
por: Fodor, Zsuzsanna, et al.
Publicado: (2021)

Heterogeneity of Alzheimer’s disease: consequence for drug trials?
por: Devi, Gayatri, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i25of4tqmijtaju2gq36s9hf6q