Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study

BACKGROUND: Modular polyketide synthases are multifunctional megasynthases which biosynthesize a variety of secondary metabolites using various combinations of dehydratase (DH), ketoreductase (KR) and enoyl-reductase (ER) domains. During the catalysis of various reductive steps these domains act on...

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Detalles Bibliográficos
Autores principales: Anand, Swadha, Mohanty, Debasisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422181/
https://www.ncbi.nlm.nih.gov/pubmed/22639887
http://dx.doi.org/10.1186/1472-6807-12-10