A Point Mutation in cycA Partially Contributes to the D-cycloserine Resistance Trait of Mycobacterium bovis BCG Vaccine Strains

In mycobacteria, CycA a D-serine, L- and D-alanine, and glycine transporter also functions in the uptake of D-cycloserine, an important second-line anti-tubercular drug. A single nucleotide polymorphism identified in the cycA gene of BCG was hypothesized to contribute to the increased resistance of...

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Detalles Bibliográficos
Autores principales: Chen, Jeffrey M., Uplekar, Swapna, Gordon, Stephen V., Cole, Stewart T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422274/
https://www.ncbi.nlm.nih.gov/pubmed/22912881
http://dx.doi.org/10.1371/journal.pone.0043467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422274/
https://www.ncbi.nlm.nih.gov/pubmed/22912881
http://dx.doi.org/10.1371/journal.pone.0043467

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