Discovery of a Natural Product-Like c-myc G-Quadruplex DNA Groove-Binder by Molecular Docking

The natural product-like carbamide (1) has been identified as a stabilizer of the c-myc G-quadruplex through high-throughput virtual screening. NMR and molecular modeling experiments revealed a groove-binding mode for 1. The biological activity of 1 against the c-myc G-quadruplex was confirmed by it...

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Detalles Bibliográficos
Autores principales: Ma, Dik-Lung, Chan, Daniel Shiu-Hin, Fu, Wai-Chung, He, Hong-Zhang, Yang, Hui, Yan, Siu-Cheong, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422278/
https://www.ncbi.nlm.nih.gov/pubmed/22912844
http://dx.doi.org/10.1371/journal.pone.0043278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422278/
https://www.ncbi.nlm.nih.gov/pubmed/22912844
http://dx.doi.org/10.1371/journal.pone.0043278

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