Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

To enhance the drug-like properties of the endogenous opioid peptide endomorphin-1 (1 = Tyr-Pro-Trp-Phe-NH(2)), the N-terminus of the peptide was modified with 2-aminodecanoic acid, resulting in compound 3. Tyr in compound 1 was replaced with 2,6-dimethyltyrosine yielding compound 2. Derivative 2 wa...

Descripción completa

Detalles Bibliográficos
Autores principales: Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T., Toth, Istvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422351/
https://www.ncbi.nlm.nih.gov/pubmed/22912681
http://dx.doi.org/10.1371/journal.pone.0041909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422351/
https://www.ncbi.nlm.nih.gov/pubmed/22912681
http://dx.doi.org/10.1371/journal.pone.0041909

Ejemplares similares