Bone progenitor dysfunction induces myelodysplasia and secondary leukemia

Mesenchymal cell populations contribute to microenvironments regulating stem cells and the growth of malignant cells. Osteolineage cells participate in the hematopoietic stem cell niche. Here, we report that deletion of the miRNA processing endonuclease Dicer1 selectively in mesenchymal osteoprogeni...

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Detalles Bibliográficos
Autores principales: Raaijmakers, Marc H.G.P., Mukherjee, Siddhartha, Guo, Shangqin, Zhang, Siyi, Kobayashi, Tatsuya, Schoonmaker, Jesse A., Ebert, Benjamin L., Al-Shahrour, Fatima, Hasserjian, Robert P., Scadden, Edward O., Aung, Zinmar, Matza, Marc, Merkenschlager, Matthias, Lin, Charles, Rommens, Johanna M., Scadden, David. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422863/
https://www.ncbi.nlm.nih.gov/pubmed/20305640
http://dx.doi.org/10.1038/nature08851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422863/
https://www.ncbi.nlm.nih.gov/pubmed/20305640
http://dx.doi.org/10.1038/nature08851

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